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1

Antitumor activity of yunnanmycin, a novel pyrimidine nucleoside antibiotic

Yong-su Zhen, Chang-qing Qi, Ji-lan Hu, Yu-chuan Xue, Wen-jun Chen

Journal:

Clinical Biochemistry

Year:

1997

Language:

english

File:

PDF, 127 KB

english, 1997

2

Three cyclohexene oxides from Uvaria grandiflora

Liao Yong-Hong, Xu Li-Zhen, Yang Shi-Lin, Dai Jie, Zhen Yong-Su, Zhu Min, Sun Nan-Jun

Journal:

Year:

1997

Language:

english

File:

PDF, 220 KB

english, 1997

3

Potentiation of antimetabolite antitumor activity in vivo by dipyridamole and amphotericin B

Shou-song Cao, Yong-su Zhen

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1989

Language:

english

File:

PDF, 559 KB

english, 1989

4

Mode of action of C-1027, a new macromolecular antitumor antibiotic with highly potent cytotoxicity, on human hepatoma BEL-7402 cells

Yong-jie Xu, Dian-dong Li, Yong-su Zhen

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1990

Language:

english

File:

PDF, 642 KB

english, 1990

5

HERG K+channel expression-related chemosensitivity in cancer cells and its modulation by erythromycin

Shu-zhen Chen, Min Jiang, Yong-su Zhen

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2005

Language:

english

File:

PDF, 419 KB

english, 2005

6

Potentiation of boanmycin antitumor activity by chemotactic peptide

Zhong-dong Li, Yi Li, Yong-su Zhen

Journal:

Chinese Journal of Cancer Research

Year:

2005

Language:

english

File:

PDF, 383 KB

english, 2005

7

Enediyne lidamycin induces apoptosis in human multiple myeloma cells through activation of p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase

Yong-Zhan Zhen, Ya-Jun Lin, Bo-Yang Shang, Yong-Su Zhen

Journal:

International Journal of Hematology

Year:

2009

Language:

english

File:

PDF, 535 KB

english, 2009

8

Anticancer activity of sodium caffeate and its mechanism

Feng XU, Sheng-hua ZHANG, Rong-guang SHAO, Yong-su ZHEN

Journal:

Acta Pharmacologica Sinica

Year:

2005

Language:

english

File:

PDF, 144 KB

english, 2005

9

Synergy of gemcitabine and lidamycin associated with NF-κB downregulation in pancreatic carcinoma cells

Jing CHEN, Shu-ying WU, Zhi-gang OU-YANG, Yong-su ZHEN

Journal:

Acta Pharmacologica Sinica

Year:

2008

Language:

english

File:

PDF, 1.85 MB

english, 2008

10

Lidamycin shows highly potent cytotoxic to myeloma cells and inhibits tumor growth in mice

Zhen, Yong-zhan, Lin, Ya-jun, Li, Yi, Zhen, Yong-su

Journal:

Acta Pharmacologica Sinica

Year:

2009

Language:

english

File:

PDF, 3.08 MB

english, 2009

11

Silencing of hdm2 oncogene by siRNA inhibits p53-dependent human breast cancer

Liu, Tie-gang, Yin, James Q, Shang, Bo-yang, Min, Zhang, He, Hong-wei, Jiang, Jian-ming, Chen, Fang, Zhen, Yong-su, Shao, Rong-guang

Journal:

Cancer Gene Therapy

Year:

2004

Language:

english

File:

PDF, 311 KB

english, 2004

12

Pingyangmycin downregulates the expression of EGFR and enhances the effects of cetuximab on esophageal cancer cells and the xenograft in athymic mice

Jian-hua Gong, Xiu-jun Liu, Yi Li, Yong-su Zhen

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 620 KB

english, 2012

13

Amphotericin B renders stationary phase hepatoma cells sensitive to dipyridamole

Yong-su Zhen, Melissa A. Reardon, George Weber

Journal:

Biochemical and Biophysical Research Communications

Year:

1986

Language:

english

File:

PDF, 284 KB

english, 1986

14

Amphotericin B: A biological response modifier in targeting against the salvage pathways

Zhen Yong-Su, Melissa A. Reardon, George Weber

Journal:

Biochemical Pharmacology

Year:

1987

Language:

english

File:

PDF, 553 KB

english, 1987

15

Endostar, a modified recombinant human endostatin, exhibits synergistic effects with dexamethasone on angiogenesis and hepatoma growth

Xing-Qi Li, Bo-Yang Shang, Dong-Chun Wang, Sheng-Hua Zhang, Shu-Ying Wu, Yong-Su Zhen

Journal:

Year:

2011

Language:

english

File:

PDF, 1.31 MB

english, 2011

16

Multi-enzyme-targeted chemotherapy by acivicin and actinomycin

George Weber, Noemi Prajda, May S. Lui, Joan E. Denton, Takashi Aoki, Judith Sebolt, Yong-Su Zhen, M.E. Burt, Mary A. Faderan, Melissa A. Reardon

Journal:

Advances in Enzyme Regulation

Year:

1982

Language:

english

File:

PDF, 962 KB

english, 1982

17

Salvage pathways as targets of chemotherapy

George Weber, Hiremagalur N. Jayaram, Konrad Pillwein, Yutaka Natsumeda, Melissa A. Reardon, Yong-Su Zhen

Journal:

Advances in Enzyme Regulation

Year:

1987

Language:

english

File:

PDF, 857 KB

english, 1987

18

Antibody-based conjugates and fusion proteins for cancer

Journal:

Journal of Biotechnology

Year:

2008

Language:

english

File:

PDF, 60 KB

english, 2008

19

Antibiotic C3368-A, a fungus-derived nucleoside transport inhibitor, potentiates the activity of antitumor drugs

Jian Su, Yong-su Zhen, Chang-qing Qi, Ji-lan Hu

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1995

Language:

english

File:

PDF, 631 KB

english, 1995

20

Antitumor Components from an Actinomycete Strain 6011W

Jiang, Xiao-Feng, Shang, Bo-Yang, Jin, Lian-Fang, Hu, Ji-Lan, Zhen, Yong-Su

Journal:

Journal of Asian Natural Products Research

Year:

1999

Language:

english

File:

PDF, 411 KB

english, 1999

21

A cell penetrating peptide-integrated and enediyne-energized fusion protein shows potent antitumor activity

Ru, Qin, Shang, Bo-yang, Miao, Qing-fang, Li, Liang, Wu, Shu-ying, Gao, Rui-juan, Zhen, Yong-su

Journal:

European Journal of Pharmaceutical Sciences

Year:

2012

Language:

english

File:

PDF, 980 KB

english, 2012

22

An NGR-integrated and enediyne-energized apoprotein shows CD13-targeting antitumor activity

Zheng, Yan-bo, Shang, Bo-yang, Li, Yi, Zhen, Yong-su

Journal:

Biomedicine & Pharmacotherapy

Year:

2013

Language:

english

File:

PDF, 1.01 MB

english, 2013

23

Synergy of enediyne antibiotic lidamycin and temozolomide in suppressing glioma growth with potentiated apoptosis induction

Li, Xing-Qi, Ouyang, Zhi-Gang, Zhang, Sheng-Hua, Liu, Hong, Shang, Yue, Li, Yi, Zhen, Yong-Su

Journal:

Journal of Neuro-Oncology

Year:

2014

Language:

english

File:

PDF, 4.05 MB

english, 2014

24

A Single Binding Mode of Activated Enediyne C1027 Generates Two Types of Double-Strand DNA Lesions: Deuterium Isotope-Induced Shuttling between Adjacent Nucleotide Target Sites

Xu, Yong-jie, Xi, Zhen, Zhen, Yong-su, Goldberg, Irving H.

Journal:

Year:

1995

Language:

english

File:

PDF, 3.07 MB

english, 1995

25

Tuftsin-based, EGFR-targeting fusion protein and its enediyne-energized analog show high antitumor efficacy associated with CD47 down-regulation

Liu, Wen-Juan, Liu, Xiu-Jun, Li, Liang, Li, Yi, Zhang, Sheng-Hua, Zhen, Yong-Su

Journal:

Cancer Immunology, Immunotherapy

Year:

2014

Language:

english

File:

PDF, 2.21 MB

english, 2014

26

Enediyne C1027 Induces the Formation of Novel Covalent DNA Interstrand Cross-Links and Monoadducts

Xu, Yong-jie, Zhen, Yong-su, Goldberg, Irving H.

Journal:

Journal of the American Chemical Society

Year:

1997

Language:

english

File:

PDF, 132 KB

english, 1997

27

Mechanism of Formation of Novel Covalent Drug·DNA Interstrand Cross-Links and Monoadducts by Enediyne Antitumor Antibiotics †

Xu, Yong-jie, Xi, Zhen, Zhen, Yong-su, Goldberg, Irving H.

Journal:

Year:

1997

Language:

english

File:

PDF, 341 KB

english, 1997

28

A tumor-targeting dextran–apoprotein conjugate integrated with enediyne chromophore shows highly potent antitumor efficacy

Li, Bin, Liu, Xiu-jun, Li, Liang, Zhang, Sheng-hua, Li, Yi, Li, Dian-dong, Zhen, Yong-su

Journal:

Polymer Chemistry

Year:

2014

Language:

english

File:

PDF, 2.58 MB

english, 2014

29

Preparation and Evaluation of a CD13/APN-Targeting and Hydrolase-Resistant Conjugate that Comprises Pingyangmycin and NGR Motif-Integrated Apoprotein

Li, Bin, Zheng, Yan-Bo, Li, Dian-Dong, Zhen, Yong-Su

Journal:

Journal of Pharmaceutical Sciences

Year:

2014

Language:

english

File:

PDF, 933 KB

english, 2014

30

Rhein Lysinate Suppresses the Growth of Tumor Cells and Increases the Anti-Tumor Activity of Taxol in Mice

Lin, Ya-Jun, Zhen, Yong-Zhan, Shang, Bo-Yang, Zhen, Yong-Su

Journal:

The American Journal of Chinese Medicine

Year:

2009

Language:

english

File:

PDF, 206 KB

english, 2009

31

Synergistic inhibition of angiogenesis and glioma cell-induced angiogenesis by the combination of temozolomide and enediyne antibiotic lidamycin

Li, Xing-qi, Ouyang, Zhi-gang, Zhang, Sheng-hua, Liu, Hong, Shang, Yue, Li, Yi, Zhen, Yong-su

Journal:

Cancer Biology & Therapy

Year:

2014

Language:

english

File:

PDF, 3.05 MB

english, 2014

32

Bortezomid enhances the efficacy of lidamycin against human multiple myeloma cells

Zhen, Yong-Zhan, Lin, Ya-Jun, Liu, Xiu-Jun, Shang, Bo-Yang, Zhen, Yong-Su

Journal:

Anti-Cancer Drugs

Year:

2013

Language:

english

File:

PDF, 589 KB

english, 2013

33

Enediyne Anticancer Antibiotic Lidamycin: Chemistry, Biology and Pharmacology

Shao, Rong-guang, Zhen, Yong-su

Journal:

Anti-Cancer Agents in Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 249 KB

english, 2008

34

Cinnamamide, an antitumor agent with low cytotoxicity acting on matrix metalloproteinase

Jiang, Xiao-feng, Zhen, Yong-su

Journal:

Anti-Cancer Drugs

Year:

2000

Language:

english

File:

PDF, 113 KB

english, 2000

35

Genetically engineered endostatin-lidamycin fusion proteins effectively inhibit tumor growth and metastasis

Jiang, Wen-guo, Lu, Xin-an, Shang, Bo-yang, Fu, Yan, Zhang, Sheng-hua, Zhou, Daifu, Li, Liang, Li, Yi, Luo, Yongzhang, Zhen, Yong-su

Journal:

Year:

2013

Language:

english

File:

PDF, 1.98 MB

english, 2013

36

Rhein lysinate suppresses the growth of breast cancer cells and potentiates the inhibitory effect of Taxol in athymic mice

Lin, Ya-Jun, Zhen, Yong-Su

Journal:

Anti-Cancer Drugs

Year:

2009

Language:

english

File:

PDF, 418 KB

english, 2009

37

An enediyne-energized single-domain antibody-containing fusion protein shows potent antitumor activity

Miao, Qing-fang, Liu, Xiao-yun, Shang, Bo-yang, Ouyang, Zhi-gang, Zhen, Yong-su

Journal:

Anti-Cancer Drugs

Year:

2007

Language:

english

File:

PDF, 320 KB

english, 2007

38

Enediyne lidamycin enhances the effect of epidermal growth factor receptor tyrosine kinase inhibitor, gefitinib, in epidermoid carcinoma A431 cells and lung carcinoma H460 cells

Liu, Hong, Li, Liang, Li, Xing-Qi, Liu, Xiu-Jun, Zhen, Yong-Su

Journal:

Anti-Cancer Drugs

Year:

2009

Language:

english

File:

PDF, 408 KB

english, 2009

39

MMP-2/9-oriented combinations enhance antitumor efficacy of EGFR/HER2-targeting fusion proteins and gemcitabine

Qin, Ye, Liu, Xiu-Jun, Li, Liang, Liu, Xu-Jie, Li, Yi, Gao, Rui‑Juan, Shao, Rong-Guang, Zhen, Yong-Su

Journal:

Oncology Reports

Year:

2014

Language:

english

File:

PDF, 1.10 MB

english, 2014

40

A Novel Nitrobenzoate Microtubule Inhibitor that Overcomes Multidrug Resistance Exhibits Antitumor Activity

Zheng, Yan-Bo, Gong, Jian-Hua, Liu, Xiu-Jun, Wu, Shu-Ying, Li, Yi, Xu, Xian-Dong, Shang, Bo-Yang, Zhou, Jin-Ming, Zhu, Zhi-Ling, Si, Shu-Yi, Zhen, Yong-Su

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 2.46 MB

english, 2016

41

EZH2 mediates lidamycin-induced cellular senescence through regulating p21 expression in human colon cancer cells

Sha, Ming-Quan, Zhao, Xiao-Li, Li, Liang, Li, Li-Hui, Li, Yi, Dong, Tian-Geng, Niu, Wei-Xin, Jia, Li-Jun, Shao, Rong-Guang, Zhen, Yong-Su, Wang, Zhen

Journal:

Cell Death and Disease

Year:

2016

Language:

english

File:

PDF, 2.37 MB

english, 2016

42

A new macromolecular antitumor antibiotic, C-1027. III. Antitumor activity.

ZHEN, YONG-SU, MING, XIU-YING, YU, BIN, OTANI, TOSHIO, SAITO, HITOSHI, YAMADA, YUJI

Journal:

The Journal of Antibiotics

Year:

1989

Language:

english

File:

PDF, 316 KB

english, 1989

43

A CD13-targeting peptide integrated protein inhibits human liver cancer growth by killing cancer stem cells and suppressing angiogenesis

Zheng, Yan-Bo, Gong, Jian-Hua, Liu, Xiu-Jun, Li, Yi, Zhen, Yong-Su

Journal:

Molecular Carcinogenesis

Year:

2017

Language:

english

File:

PDF, 1.12 MB

english, 2017

44

Recombinant EGFR/MMP-2 bi-targeted fusion protein markedly binding to non-small-cell lung carcinoma and exerting potent therapeutic efficacy

Xu, Jian, Du, Yue, Liu, Xiu-Jun, Zhu, Bing-Yan, Zhang, Sheng-Hua, Li, Liang, Li, Yi, Wang, Xiao-Fei, Shan, Chuan-Kun, Wang, Rui-Qi, Zhen, Yong-Su

Journal:

Pharmacological Research

Year:

2017

Language:

english

File:

PDF, 1.81 MB

english, 2017

45

Antitumor activities of dFv-LDP-AE: An enediyne-energized fusion protein targeting tumor-associated antigen gelatinases

Journal:

Oncology Reports

Year:

2012

Language:

english

File:

PDF, 601 KB

english, 2012

46

Down-regulation of the nuclear factor-κB by lidamycin in association with inducing apoptosis in human pancreatic cancer cells and inhibiting xenograft growth

Chen, Jing, Ouyang, Zhi-gang, Zhang, Sheng-hua, Zhen, Yong-su

Journal:

Oncology Reports

Year:

2007

Language:

english

File:

PDF, 223 KB

english, 2007

47

Intensive fibrosarcoma-binding capability of the reconstituted analog and its antitumor activity

Xu, Jian, Du, Yue, Liu, Wen-Juan, Li, Liang, Li, Yi, Wang, Xiao-Fei, Yi, Hong-Fei, Shan, Chuan-Kun, Xia, Gui-Min, Liu, Xiu-Jun, Zhen, Yong-Su

Journal:

Year:

2018

Language:

english

File:

PDF, 2.08 MB

english, 2018

48

EGFR-targeting, β-defensin-tailored fusion protein exhibits high therapeutic efficacy against EGFR-expressed human carcinoma via mitochondria-mediated apoptosis

Liu, Wen-Juan, Liu, Xiu-Jun, Xu, Jian, Li, Liang, Li, Yi, Zhang, Sheng-Hua, Wang, Jia-Lin, Miao, Qing-Fang, Zhen, Yong-Su

Journal:

Acta Pharmacologica Sinica

Year:

2018

Language:

english

File:

PDF, 2.31 MB

english, 2018

49

A recombinantly tailored β-defensin that displays intensive macropinocytosis-mediated uptake exerting potent efficacy against K-Ras mutant pancreatic cancer

Du, Yue, Shang, Bo-yang, Sheng, Wei-jin, Zhang, Sheng-hua, Li, Yi, Miao, Qing-fang, Zhen, Yong-su

Journal:

Year:

2016

Language:

english

File:

PDF, 12.17 MB

english, 2016

50

A ligand-based and enediyne-energized bispecific fusion protein targeting epidermal growth factor receptor and insulin-like growth factor-1 receptor shows potent antitumor efficacy against esophageal cancer

Cao, Hai-Ying, Guo, Xiao-Fang, Zhu, Xiao-Fei, Li, Sai-Sai, Zhen, Yong-Su

Journal:

Oncology Reports

Year:

2017

Language:

english

File:

PDF, 1.04 MB

english, 2017

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